{"id":10405,"date":"2026-11-12T04:16:29","date_gmt":"2026-11-12T04:16:29","guid":{"rendered":"https:\/\/silvybrand.com\/?p=10405"},"modified":"2026-11-12T04:16:29","modified_gmt":"2026-11-12T04:16:29","slug":"a-new-benchmark-for-de-aging-comes-from-slowly-turning-back-cells-clocks","status":"publish","type":"post","link":"https:\/\/silvybrand.com\/?p=10405","title":{"rendered":"A New Benchmark for De-Aging Comes From Slowly Turning Back Cells\u2019 Clocks"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p><span class=\"body lead-in-text\">Scientists have long<\/span> known how to make cells younger\u2014at least in the sense that adult cells can be converted into <a href=\"https:\/\/www.wired.com\/story\/japan-approves-the-worlds-first-treatment-made-with-reprogrammed-human-cells\/\" class=\"text link\">pluripotent stem cells<\/a> very similar to those found in embryos. While this capability has been foundational for biological research, these methods aren\u2019t viable for <a href=\"https:\/\/www.wired.com\/story\/new-anti-aging-drug-trial-for-skin\/\" class=\"text link\">anti-aging technologies<\/a>, for a few reasons.<\/p>\n<p class=\"paywall\">\u201cYou don&#8217;t want to have a pluripotent cell in your body, because it can become all types of cells,\u201d says Oliver Br\u00fcstle, a professor who studies stem cells at Germany\u2019s Bonn University.<\/p>\n<p class=\"paywall\">Additionally, the few key genes involved in the stem cell conversion process can drive the <a href=\"https:\/\/www.wired.com\/story\/new-melanoma-vaccine-reduces-risk-of-tumor-reoccurrence-by-over-40-percent\/\" class=\"text link\">formation of cancer<\/a> if left active. That\u2019s why Br\u00fcstle and his team have looked for other ways of de-aging cells without going through a pluripotent state. In their recent study published in <a data-offer-url=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751\" class=\"external-link text link\" data-event-click=\"{&quot;element&quot;:&quot;ExternalLink&quot;,&quot;outgoingURL&quot;:&quot;https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751&quot;}\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751\" rel=\"nofollow noopener\" target=\"_blank\">Aging Cell<\/a>, the researchers started with blood cells from people of various ages, including an infant and a 101-year-old donor.<\/p>\n<p class=\"paywall\">They guided these cells into a younger state but not all the way toward becoming embryonic-like stem cells. And as this transformation progressed, the chemical signals in the DNA that help estimate a cell\u2019s age also changed. In less than two months of reprogramming, one biomarker in particular was set back as far as 60 years.<\/p>\n<p class=\"paywall\">Aging continued to reverse even when the scientists drastically reduced the cells\u2019 ability to multiply. Therefore, the apparent rejuvenation can\u2019t be explained solely by the fact that the cells were dividing and producing new cells over and over again. However, the mechanism that did erase these signs of aging is still unclear.<\/p>\n<p class=\"paywall\">\u201cThe hope is that you actually can do this systemically in the <a href=\"https:\/\/www.wired.com\/story\/a-billionaire-backed-startup-wants-to-grow-organ-sacks-to-replace-animal-testing\/\" class=\"text link\">entire animal<\/a>,\u201d Br\u00fcstle says. \u201cBut if you think about applying it in a patient, then you want to be sure this is not a lab experiment, so it&#8217;s about finding the mechanism.\u201d<\/p>\n<p class=\"paywall\">The researchers also shifted the blood cells specifically into a kind of cell that produces neurons. One caveat is that blood cells and <a href=\"https:\/\/www.wired.com\/story\/poor-sleep-quality-accelerates-brain-aging\/\" class=\"text link\">neurons age<\/a> on different timelines, so the extent of the reversal could be exaggerated by the use of a different measuring stick. The authors acknowledge this limitation in their paper, though this discrepancy couldn\u2019t account for all the age-associated biomarkers that reversed course.<\/p>\n<p class=\"paywall\">Blood cells getting brainy also would not be a desirable result if you <a href=\"https:\/\/www.wired.com\/story\/longevity-startup-doses-first-human-in-bid-to-reverse-age-related-sight-loss\/\" class=\"text link\">gave a patient<\/a> a de-aging drug, but it would be useful for other regenerative medicine purposes. However, what Br\u00fcstle sees as one of the most exciting outcomes of the study is the information gleaned about the process of de-aging.<\/p>\n<p class=\"paywall\">Usually, making stem cells is quick. That\u2019s useful for many experiments, but it doesn\u2019t give researchers the chance to study cells as they shed the <a href=\"https:\/\/www.wired.com\/story\/data-holds-the-key-in-slowing-age-related-illnesses\/\" class=\"text link\">markers of age<\/a>. In this recent study, since the scientists were able to slowly turn back the cells\u2019 biological clocks, they could track each step of de-aging. \u201cNow we can actually try to dissect the process much more easily than having an instantaneous event,\u201d Br\u00fcstle says.<\/p>\n<p class=\"paywall\">Scientists began converting adult cells back into stem cells two decades ago, but we\u2019ve known very little about how the subsequent de-aging occurs. This means when clinical researchers test <a href=\"https:\/\/www.wired.com\/story\/british-space-startup-launches-longevity-lab-into-orbit\/\" class=\"text link\">potential medical interventions<\/a> for age-related conditions, they haven\u2019t always had a reliable measure to compare against.<\/p>\n<p class=\"paywall\">\u201cNow we have a model\u201d Br\u00fcstle says. \u201cYou can work along this, and now you can probe a zillion things. What impacts the process? This will lead you to the mechanisms. That\u2019s our hope.\u201d<\/p>\n<p class=\"paywall\"><em>Additional reporting from Anna Rogers.<\/em><\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.wired.com\/story\/a-new-benchmark-for-de-aging-comes-from-slowly-turning-back-cells-clocks\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have long known how to make cells younger\u2014at least in the sense that adult cells can be converted into pluripotent stem cells very similar to those found in embryos. While this capability has been foundational for biological research, these methods aren\u2019t viable for anti-aging technologies, for a few reasons. \u201cYou don&#8217;t want to have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10406,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[1418,141,584,1561,1369,1648],"class_list":["post-10405","post","type-post","status-publish","format-standard","has-post-thumbnail","category-gadgets","tag-aging","tag-health","tag-neuroscience","tag-personalized-medicine","tag-regenerative-medicine","tag-stem-cells"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A New Benchmark for De-Aging Comes From Slowly Turning Back Cells\u2019 Clocks - Silvybrand Lifestyle Blog<\/title>\n<meta name=\"description\" content=\"Researchers in Germany gradually reversed human cells\u2019 ages by decades. 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