{"id":2397,"date":"2026-06-19T15:22:24","date_gmt":"2026-06-19T15:22:24","guid":{"rendered":"https:\/\/silvybrand.com\/?p=2397"},"modified":"2026-06-19T15:22:24","modified_gmt":"2026-06-19T15:22:24","slug":"ebola-vaccine-sitting-on-shelf-for-15-years","status":"publish","type":"post","link":"https:\/\/silvybrand.com\/?p=2397","title":{"rendered":"The Most Promising Ebola Vaccine Has Been Sitting on the Shelf for 15 Years"},"content":{"rendered":"<p><br \/>\n<\/p>\n<div>\n<p class=\"paywall\">\u201cWe thought that\u2019s probably the one that\u2019s least likely to pop up,\u201d Geisbert says. \u201cWe guessed wrong.\u201d<\/p>\n<p class=\"paywall\">Concerned by that knowledge gap, in 2011 he decided to modify a vaccine, which led to the crab-eating macaque study. In the same study, he also finally tested a blend of existing ebola vaccines on the Bundibugyo strain, but they didn\u2019t provide 100-percent protection.<\/p>\n<p class=\"paywall\">If the 2012 outbreak had occurred after the major Zaire outbreak, Geisbert says, it\u2019s possible pharmaceutical companies might\u2019ve been more keen to commercialize a vaccine that protects against the Bundibugyo strain.<\/p>\n<p class=\"paywall\">But with the present outbreak rivaling the 2013 to 2016 one in terms of scale and scope, efforts to play catch-up are going into high gear. Geisbert suspects WHO\u2019s experience with Ervebo is one of the reasons they favor his vaccine candidate, which is basically \u201cBundibugyo Ervebo,\u201d he says.<\/p>\n<p class=\"paywall\">WHO also noted the success of a similar rVSV-based vaccine targeting the Sudan strain of ebola in a ring vaccination trial in 2025.<\/p>\n<p class=\"paywall\">The rVSV-based Bundibugyo candidate\u2019s suitability for ring vaccination was backed by a 2023 study showing most of the monkeys were protected from the virus even after they were exposed if they had been vaccinated. That is crucial for ring vaccination to work. While the researchers vaccinated the monkeys an unrealistically quick 20 minutes after exposure, the proof of concept sets it apart from Moderna and the University of Oxford\u2019s candidates under development.<\/p>\n<p class=\"paywall\">\u201cThere hasn\u2019t really been much development since that 2023 study, because we weren\u2019t really expecting to see that strain and also because historically it&#8217;s been associated with lower-rate mortality as well,\u201d said Courtney Woolsey, the lead author on the paper (Geisbert was a coauthor) and an assistant professor within the University of Texas Medical Branch.<\/p>\n<p class=\"paywall\">\u201cNobody really makes money off these vaccines,\u201d she adds, \u201cso there are funding barriers as well to advance these vaccines where people likely aren\u2019t going to make money.\u201d<\/p>\n<p class=\"paywall\">The nonprofit Coalition for Epidemic Preparedness Innovations has offered funding of up to $3.2 million to prepare and start testing the material needed to manufacture Gesbert\u2019s vaccine, which would be the first step towards human trials.<\/p>\n<p class=\"paywall\">The \u201cextensive safety data and prior regulatory experience\u201d from the rVSV-based vaccines used to combat the Zaire strain \u201ccould help expedite approval pathways if it is shown to be successful,\u201d Rachael Bonawitz, filovirus disease programme lead at CEPI, tells WIRED over email, adding that developers would also be able to build on existing manufacturing processes.<\/p>\n<p class=\"paywall\">\u201cEven if it\u2019s not used in this outbreak, hopefully there will be clinical material that can be used in humans available for the next outbreak,\u201d Geisbert says, \u201cbecause it will probably pop up again.\u201d<\/p>\n<p class=\"paywall\">Even as it shows promise, there is still a chance his vaccine won\u2019t work. Scientists have not been able to obtain a live Bundibugyo virus sample for testing due to stretched resources in the DRC and the logistical and bureaucratic complexity of obtaining and transporting refrigerated blood back to the US. While scientists believe the current strain is around 98-percent similar to the strain that caused the previous outbreaks, that unknown 2 percent presents a risk the vaccine won\u2019t be as effective as it was against the previous strain.<\/p>\n<p class=\"paywall\">\u201cWhen you look at the sequences it\u2019s not different enough that I would predict that there would be a problem, but nothing\u2019s foolproof,\u201d Geisbert says.<\/p>\n<p class=\"paywall\">The International AIDS Vaccine Initiative in New York will prepare the vaccine candidate for production. The nonprofit biomedical research organization focuses on developing vaccines for global diseases where there is little financial incentive for development.<\/p>\n<p class=\"paywall\">\u201cThe baton has been handed off, and I just sit back and hope that it works, whether it\u2019s the vaccine, whether it\u2019s somebody else\u2019s vaccine,\u201d Geisbert says.<\/p>\n<\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.wired.com\/story\/ebola-vaccine-sitting-on-shelf-for-15-years\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cWe thought that\u2019s probably the one that\u2019s least likely to pop up,\u201d Geisbert says. \u201cWe guessed wrong.\u201d Concerned by that knowledge gap, in 2011 he decided to modify a vaccine, which led to the crab-eating macaque study. In the same study, he also finally tested a blend of existing ebola vaccines on the Bundibugyo strain, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2398,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[780,148,141,626],"class_list":["post-2397","post","type-post","status-publish","format-standard","has-post-thumbnail","category-gadgets","tag-biotech","tag-ebola","tag-health","tag-vaccines"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Most Promising Ebola Vaccine Has Been Sitting on the Shelf for 15 Years - Silvybrand Lifestyle Blog<\/title>\n<meta name=\"description\" content=\"Years after initial tests, researchers are now racing to see if a vaccine developed in 2011 can help fight the current Bundibugyo outbreak in Congo.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/silvybrand.com\/?p=2397\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Most Promising Ebola Vaccine Has Been Sitting on the Shelf for 15 Years - 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